By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play a massive function in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step strategy: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated through numerous varied hormones. The sodium channels additionally play an important function in a couple of sickness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range presents the 1st in-depth trade of rules referring to those sodium channels, their rules and involvement in basic and pathophysiological occasions. Key good points * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal law of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents principles on sodium channels and disorder
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Additional info for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
Awayda, M. , Arrate, M. , Bradford, A. , Morns, R. , Canessa, C. , Rossier, B. , and Benos, D. J. (1995). Cloning of a bovine renal epithelial Na+ channel subunit. Am. J. Physiol. 269, C641-C654. Fuller, C. , Ismailov, I. , Berdiev, B. , Shlyonsky, V. , and Benos, D. J. (1996). Kinetic interconversion of rat and bovine homologs of the ct subunit of an amiloride-sensitive Na' channel by C-terminal truncation of the bovine subunit. J. Biol. Chem. 271,26602-26608. Fuller, C. , Berdiev, B. , Shlyonsky, V.
1995). 8IArnil. 2- FIGURE 3 Expression of hENaC subunits in Xenopus oocytes. Amiloride-sensitive whole-cell Na' current in oocytes (-60 mV) one day after injection of either vector (pMT3) or hENaC subunits, as indicated. Current is expressed relative to cells expressing apyhENaC. Adapted from McDonald et al. (1995). 30 Peter M. Snyder et al. , 1994b) and suggest that all three subunits contribute to the functional Na+ channel complex. IV. STOICHIOMETRY OF hENaC A. Electrophysiologid Analysis The finding that coexpression of a,p, and yENaC is required for maximal Na+ current suggests that ENaC is a heteromultimeric channel.
Physiol. 254, C802-C808. Li. , Guggino, W. , and Snyder, S. H. (1995). Alternatively spliced forms of the a subunit of the epithelial sodium channel: Distinct sites for amiloride binding and channel pore. Mol. Pharmncol. 47, 1133-1140. , and Barbry, P. (1995). Cloning of the amiloridesensitive FMRFamide peptide-gated sodium channel. Nature (London) 378, 730-733. , and Eaton, D. C. (1991). Effects of vasopressin and CAMPon single amilorideblockade Na channels. Am. J. Physiol. 260, C1071-C1084. Oh, Y .
Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)